Positive regulation of T cell receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of T cell receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CARD11, PTPN6, and RUNX3_T14, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of T cell receptor signaling pathway activity versus CARD11 in LSCC (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CARD11 →	+0.577	+0.096	<.001	<.001	3	8
BRCA	PTPN6 →	+0.377	+0.054	<.001	<.001	3	8
BRCA	RUNX3_T14 →	+0.626	+0.042	<.001	<.001	3	7
LSCC	SERPINB9 →	+0.448	+0.094	<.001	<.001	3	7
LSCC	TBC1D2B →	+0.206	+0.074	<.001	<.001	3	7
LSCC	WDFY4 →	+0.480	+0.091	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050862 vs CARD11 — LSCC

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