Positive regulation of T cell receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of T cell receptor signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NECTIN2, DENND1B, and ADA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NECTIN2 grouped by Positive regulation of T cell receptor signaling pathway-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NECTIN2 →	-0.169	-0.621	.004	.003	3	5
STOMACH	DENND1B →	-0.130	-0.248	.002	.003	3	4
BONE	ADA →	-0.454	-0.385	<.001	<.001	3	4
LARGE_INTESTINE	NDUFS5 →	-0.375	-0.260	.004	.004	3	3
SOFT_TISSUE	GH2 →	+0.238	+0.355	.003	.006	3	3
SOFT_TISSUE	VSNL1 →	+0.181	+0.292	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NECTIN2 by Positive regulation of T cell receptor signaling pathway activity — LARGE_INTESTINE

Explore this box plot interactively →