Regulation of steroid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Regulation of steroid biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RSU1, SNRPG, and CTHRC1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of steroid biosynthetic process activity versus RSU1 in OV (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RSU1 →	+0.305	+0.034	<.001	<.001	3	7
BRCA	SNRPG →	-0.173	-0.034	.001	<.001	3	6
OV	CTHRC1 →	+1.081	+0.048	<.001	<.001	3	6
BRCA	PARP1 →	-0.416	-0.030	<.001	.001	3	6
OV	PDGFRB →	+0.452	+0.030	<.001	<.001	3	6
BRCA	SETDB1_S1066 →	-0.806	-0.028	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050810 vs RSU1 — OV

Explore this scatter interactively →