Negative regulation of synaptic transmission

Across TCGA patient cohorts, RNA activity of the Negative regulation of synaptic transmission pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NCF1, FGD3, and S100A12, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of synaptic transmission activity versus NCF1 in GBM (Pearson r = 0.19).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NCF1 →	+0.473	+0.039	.009	.005	3	6
BRCA	FGD3 →	+0.621	+0.021	.001	.006	3	6
COAD	S100A12 →	+0.948	+0.025	.006	.002	3	5
COAD	ITGAM →	+0.490	+0.018	<.001	.001	3	5
CCRCC	MMP8 →	+0.824	+0.048	.005	.001	3	5
GBM	SIN3A →	-0.219	-0.041	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050805 vs NCF1 — GBM

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