Negative regulation of peptidyl-tyrosine phosphorylation

Across TCGA patient cohorts, RNA activity of the Negative regulation of peptidyl-tyrosine phosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SIGLEC14, CCL4L2, and CSF3R, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of peptidyl-tyrosine phosphorylation activity versus SIGLEC14 in GBM (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SIGLEC14 →	+0.661	+0.175	.007	.002	3	4
UCEC	CCL4L2 →	+0.722	+0.291	.006	<.001	3	4
HNSC	CSF3R →	+0.782	+0.165	<.001	<.001	3	4
HNSC	NLRP3 →	+0.932	+0.168	<.001	.005	3	4
HNSC	FPR2 →	+0.659	+0.102	.003	.006	3	4
HNSC	FGR →	+0.819	+0.138	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050732 vs SIGLEC14 — GBM

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