Negative regulation of peptidyl-tyrosine phosphorylation

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of peptidyl-tyrosine phosphorylation pathway differs between tumor and matched normal tissue in 10 of the 18 cancer types tested.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as KICH and COAD, show the opposite pattern, with lower activity in tumor tissue.

HNSC, KICH, and COAD show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
HNSC	All	All	+0.030	<.001	8	view →
KICH	Female	All	−0.042	<.001	7	view →
COAD	Female	All	−0.040	<.001	6	view →
LUAD	All	All	+0.025	<.001	5	view →
STAD	All	All	+0.049	.001	4	view →
THCA	Female	All	−0.031	<.001	4	view →
CHOL	All	All	+0.055	<.001	3	view →
KIRP	All	All	−0.022	.006	3	view →
BRCA	Female	All	+0.012	.010	2	view →
KIRC	Male	All	+0.012	.012	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 10 strongest of 10 lineages.

GO:0050732–HNSC

Open the HNSC breakdown →