Negative regulation of peptidyl-tyrosine phosphorylation

Across TCGA cell cohorts, RNA activity of the Negative regulation of peptidyl-tyrosine phosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC35G1, CAMK1, and ACSF2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC35G1 grouped by Negative regulation of peptidyl-tyrosine phosphorylation-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SLC35G1 →	-1.003	-0.280	.009	.006	3	4
LUNG_SCLC	CAMK1 →	-1.196	-0.241	.007	.006	3	4
LUNG_NSCLC_LUAD	ACSF2 →	+1.158	+0.363	<.001	.001	3	4
OVARY	KLF5 →	+2.387	+0.215	<.001	.004	3	3
OVARY	TBC1D8 →	+1.033	+0.342	.001	.003	3	3
SOFT_TISSUE	PKM →	+1.241	+0.344	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC35G1 by Negative regulation of peptidyl-tyrosine phosphorylation activity — PANCREAS

Explore this box plot interactively →