Arachidonic acid secretion

Across TCGA patient cohorts, RNA activity of the Arachidonic acid secretion pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRADD, LMNB1, and ANXA2_T19, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Arachidonic acid secretion activity versus TRADD in GBM (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TRADD →	+0.273	+0.073	<.001	<.001	3	5
GBM	LMNB1 →	-0.386	-0.073	<.001	.007	3	5
CCRCC	ANXA2_T19 →	+0.524	+0.068	<.001	<.001	3	4
UCEC	FAM160B1 →	+0.205	+0.057	<.001	<.001	3	4
GBM	MRC1 →	+0.814	+0.084	<.001	.004	3	4
PDAC	RETSAT →	+0.301	+0.056	.003	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050482 vs TRADD — GBM

Explore this scatter interactively →