Arachidonic acid secretion

Across TCGA pan-cancer cohorts, RNA activity of the Arachidonic acid secretion pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 31 member genes.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher Arachidonic acid secretion pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KICH and PAAD, show the opposite pattern, with higher activity associated with better survival.

READ, LGG, and KICH are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Median	II,III,IV	0.809	0.975	<.001	77	view →
LGG	DFS	Median	All	0.653	0.810	<.001	50	view →
KICH	DFS	Median	II,III,IV	0.951	0.588	.003	41	view →
PAAD	DFS	Median	II,III,IV	0.534	0.366	.001	40	view →
UCS	DFS	Tertile	II,III,IV	0.157	0.582	.018	36	view →
SKCM	DFS	Quartile	II,III,IV	0.696	0.387	.001	30	view →
LIHC	DFS	Tertile	II,III,IV	0.582	0.292	.001	27	view →
PRAD	DFS	Median	All	0.887	0.666	<.001	26	view →
LUAD	DFS	Tertile	III,IV	0.779	0.455	.005	24	view →
OV	DFS	Median	II,III,IV	0.126	0.189	.008	20	view →
SARC	OS	Median	All	0.889	0.792	.005	19	view →
LUSC	OS	Tertile	III,IV	0.702	0.350	.013	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0050482–READ (OS)

Open the READ breakdown →