Stem cell fate commitment

Across TCGA cell cohorts, RNA activity of the Stem cell fate commitment pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GSPT1, SPAST, and INO80D, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GSPT1 grouped by Stem cell fate commitment-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	GSPT1 →	+0.843	+1.582	.005	.005	3	3
LARGE_INTESTINE	SPAST →	+0.512	+0.537	.002	.004	3	3
LUNG_NSCLC_LUAD	INO80D →	+0.374	+0.485	.001	.006	2	4
LUNG_NSCLC_LUAD	ARRDC5 →	+0.033	+0.458	.005	.009	3	3
URINARY_TRACT	NIT2 →	-0.879	-1.598	.004	.005	3	3
OVARY	EAF2 →	+0.695	+0.867	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GSPT1 by Stem cell fate commitment activity — LIVER

Explore this box plot interactively →