Stem cell development

Across TCGA cell cohorts, RNA activity of the Stem cell development pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPS27, TAF9, and ERCC8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MRPS27 grouped by Stem cell development-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	MRPS27 →	+0.469	+0.239	.005	.005	2	5
OVARY	TAF9 →	+0.949	+0.235	<.001	<.001	2	4
OVARY	ERCC8 →	+0.772	+0.199	.003	.001	3	3
OVARY	GUCY1B1 →	-2.032	-0.200	.002	.003	3	3
OESOPHAGUS	SUSD5 →	-1.212	-0.193	.003	.005	3	3
OESOPHAGUS	FARS2 →	+0.696	+0.220	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MRPS27 by Stem cell development activity — OESOPHAGUS

Explore this box plot interactively →