Stem cell development

Across TCGA pan-cancer cohorts, RNA activity of the Stem cell development pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 89 member genes.

The strongest signal is observed in thyroid carcinoma (THCA), where higher Stem cell development pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and UCS, show the opposite pattern, with higher activity associated with better survival.

THCA, HNSC, and UCS are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	OS	Median	II,III,IV	0.731	0.960	<.001	70	view →
HNSC	DFS	Median	III,IV	0.441	0.257	.002	61	view →
UCS	DFS	Quartile	III,IV	0.595	0.154	.009	44	view →
KIRP	DFS	Quartile	All	0.716	0.917	.001	42	view →
BRCA	OS	Quartile	III,IV	0.681	0.419	.001	27	view →
ACC	DFS	Median	III,IV	0.082	0.563	<.001	25	view →
ESCA	OS	Median	III,IV	0.589	0.322	.007	21	view →
TGCT	DFS	Median	All	0.525	0.781	.002	18	view →
LGG	DFS	Tertile	All	0.535	0.827	.002	16	view →
COAD	DFS	Median	III,IV	0.653	0.297	.010	15	view →
PAAD	DFS	Tertile	II,III,IV	0.590	0.357	.020	13	view →
LUAD	DFS	Median	All	0.267	0.443	.008	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:0048864–THCA (OS)

Open the THCA breakdown →