Stem cell development

Across TCGA cell cohorts, RNA activity of the Stem cell development pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMAD6, GPR176, and ADAMTS12, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Stem cell development activity versus SMAD6 in OVARY (Pearson r = -0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SMAD6 →	-1.781	-0.221	<.001	.007	3	5
BREAST	GPR176 →	+1.884	+0.244	.005	.002	3	4
URINARY_TRACT	ADAMTS12 →	+2.885	+0.355	.002	.001	3	4
URINARY_TRACT	BANK1 →	-1.171	-0.339	.001	.003	3	4
URINARY_TRACT	CYP27C1 →	-2.056	-0.390	<.001	.005	3	4
BREAST	RHOB →	-1.819	-0.199	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048864 vs SMAD6 — OVARY

Explore this scatter interactively →