Dendrite morphogenesis

Across TCGA patient cohorts, RNA activity of the Dendrite morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPIN2A, ABCC6P2, and TNMD, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dendrite morphogenesis activity versus SPIN2A in OV (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SPIN2A →	+0.712	+0.629	<.001	<.001	3	2
OV	ABCC6P2 →	+0.835	+0.590	.005	.004	3	2
COAD	TNMD →	+0.844	+0.334	.009	.002	3	2
BRCA	WNT5B →	-1.549	-0.560	.001	.002	3	1
BRCA	MYO10 →	-2.363	-0.618	.002	.002	3	1
BRCA	GPR6 →	+0.220	+0.621	.005	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048813 vs SPIN2A — OV

Explore this scatter interactively →