Dendrite morphogenesis

Across TCGA pan-cancer cohorts, RNA activity of the Dendrite morphogenesis pathway is associated with patient survival in 29 of 34 cancer lineages. Pathway activity is summarized from the expression of its 138 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Dendrite morphogenesis pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and SCLC, show the opposite pattern, with higher activity associated with better survival.

UVM, SKCM, and KICH are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	II,III,IV	0.513	0.881	.001	98	view →
SKCM	DFS	Quartile	All	0.794	0.547	<.001	54	view →
KICH	OS	Tertile	III,IV	0.125	0.835	.001	40	view →
ESCA	OS	Tertile	IV	0.135	0.568	.031	36	view →
SCLC	DFS	Tertile	II,III,IV	0.500	0.161	.005	22	view →
ACC	DFS	Tertile	All	0.453	0.889	.006	19	view →
UCS	OS	Median	II,III,IV	0.625	0.267	.010	18	view →
CESC	DFS	Quartile	II,III,IV	0.621	0.863	.006	16	view →
LUAD	DFS	Quartile	IV	0.281	1.000	.026	16	view →
MESO	OS	Median	III,IV	0.290	0.504	.002	15	view →
KIRP	DFS	Quartile	All	0.420	0.775	.002	15	view →
KIRC	DFS	Median	IV	0.205	0.401	.017	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

GO:0048813–UVM (DFS)

Open the UVM breakdown →