Pronephros development

Across TCGA cell cohorts, RNA activity of the Pronephros development pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HMGN1, TANGO2, and OR51M1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pronephros development activity versus HMGN1 in KIDNEY (Pearson r = -0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	HMGN1 →	-0.412	-0.334	<.001	.002	3	2
KIDNEY	TANGO2 →	-1.255	-0.456	.009	.001	3	1
KIDNEY	OR51M1 →	-0.027	-0.340	.004	.002	3	1
KIDNEY	BRCC3 →	-1.092	-0.325	.003	.003	2	2
KIDNEY	TMEM222 →	-1.150	-0.464	.008	<.001	3	1
KIDNEY	SRSF10 →	-0.671	-0.334	.007	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048793 vs HMGN1 — KIDNEY

Explore this scatter interactively →