Branching morphogenesis of an epithelial tube

Across TCGA cell cohorts, RNA activity of the Branching morphogenesis of an epithelial tube pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FZD3, FBXO16, and TBC1D2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FZD3 grouped by Branching morphogenesis of an epithelial tube-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	FZD3 →	+0.883	+1.141	<.001	<.001	3	4
SKIN	FBXO16 →	+0.641	+0.775	.002	.001	3	4
BONE	TBC1D2 →	-1.803	-0.955	<.001	.006	2	5
LUNG_NSCLC_LUAD	CCDC9B →	-1.836	-0.577	<.001	.006	3	4
BONE	ARHGAP29 →	-4.528	-1.224	<.001	.009	3	4
BONE	BDP1 →	+1.044	+1.293	.003	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FZD3 by Branching morphogenesis of an epithelial tube activity — SKIN

Explore this box plot interactively →