Branching morphogenesis of an epithelial tube

Across TCGA cell cohorts, RNA activity of the Branching morphogenesis of an epithelial tube pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTSZ, RBFA, and CCNP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Branching morphogenesis of an epithelial tube activity versus CTSZ in BLOOD_Leukemia (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CTSZ →	+4.167	+1.465	<.001	<.001	3	5
CNS	RBFA →	-0.735	-1.086	<.001	<.001	3	5
LARGE_INTESTINE	CCNP →	-1.538	-0.970	<.001	<.001	3	5
BREAST	POLQ →	-0.867	-0.831	<.001	.008	3	4
LUNG_SCLC	KLHL3 →	+0.969	+1.134	.001	.004	3	4
LUNG_SCLC	WDR81 →	-0.722	-1.139	.006	.003	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048754 vs CTSZ — BLOOD_Leukemia

Explore this scatter interactively →