Appendage development

Across TCGA patient cohorts, RNA activity of the Appendage development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LYRM9, FAM66A, and GTDC1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Appendage development activity versus LYRM9 in BRCA (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LYRM9 →	+1.087	+0.709	<.001	<.001	3	4
BRCA	FAM66A →	+0.703	+0.426	.003	.002	3	3
COAD	GTDC1 →	-0.225	-0.348	.005	.003	3	3
COAD	MIR548AQ →	+0.238	+0.516	.006	.006	3	3
PDAC	HIP1R →	+0.378	+0.216	.007	.005	3	3
HNSC	RHOB →	+0.905	+0.627	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048736 vs LYRM9 — BRCA

Explore this scatter interactively →