Epidermis morphogenesis

Across TCGA cell cohorts, RNA activity of the Epidermis morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ORC4, ARHGAP17, and CCNT1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ORC4 grouped by Epidermis morphogenesis-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ORC4 →	+0.102	+0.110	.002	.001	3	4
BLOOD_Leukemia	ARHGAP17 →	+0.196	+0.120	.007	.002	2	5
UPPER_AERODIGESTIVE_TRACT	CCNT1 →	+0.126	+0.241	<.001	.001	3	3
URINARY_TRACT	AGAP2 →	+0.205	+0.239	.004	<.001	3	3
SOFT_TISSUE	UGT1A7 →	+0.455	+0.263	.001	.007	3	3
BLOOD_Myeloma	TOPBP1 →	+0.362	+0.273	.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ORC4 by Epidermis morphogenesis activity — BREAST

Explore this box plot interactively →