Negative regulation of astrocyte differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of astrocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are B3GALT4, CEACAM19, and TRAF4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, B3GALT4 grouped by Negative regulation of astrocyte differentiation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	B3GALT4 →	+1.120	+0.697	<.001	.003	3	5
PANCREAS	CEACAM19 →	-1.511	-0.998	.003	.005	3	4
CNS	TRAF4 →	+0.370	+0.714	.008	.003	3	4
URINARY_TRACT	MSANTD3 →	-1.374	-1.937	<.001	<.001	3	4
KIDNEY	ANKRD61 →	+0.519	+1.100	<.001	<.001	3	4
LUNG_NSCLC_LUAD	LAGE3 →	+0.697	+0.548	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

B3GALT4 by Negative regulation of astrocyte differentiation activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →