Negative regulation of astrocyte differentiation

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of astrocyte differentiation pathway differs between tumor and matched normal tissue in 13 of the 18 cancer types tested.

The strongest signal is observed in thyroid carcinoma (THCA), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as BRCA and KIRC, show the opposite pattern, with lower activity in tumor tissue.

THCA, STAD, and KICH show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
THCA	Male	All	+0.112	<.001	11	view →
STAD	All	II,III,IV	+0.064	<.001	9	view →
KICH	Female	All	+0.083	<.001	6	view →
BRCA	All	III,IV	−0.078	<.001	6	view →
COAD	All	III,IV	+0.044	.008	6	view →
KIRC	Male	All	−0.032	<.001	6	view →
LIHC	Female	II,III,IV	+0.032	.010	4	view →
LUAD	Male	II,III,IV	−0.071	.001	3	view →
CHOL	All	All	+0.074	.003	2	view →
PRAD	All	All	+0.038	.001	2	view →
UCEC	All	All	−0.037	.034	2	view →
ESCA	Female	All	−0.143	.012	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 13 lineages.

GO:0048712–THCA

Open the THCA breakdown →