Positive regulation of astrocyte differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of astrocyte differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ITIH1, CFP, and AHNAK2_S260, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of astrocyte differentiation activity versus ITIH1 in PDAC (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ITIH1 →	+0.495	+0.061	<.001	<.001	3	8
BRCA	CFP →	+0.638	+0.062	<.001	<.001	3	7
UCEC	AHNAK2_S260 →	+1.283	+0.094	<.001	.004	3	7
UCEC	APOC1 →	+0.555	+0.084	.007	.008	2	8
LSCC	C3 →	+0.474	+0.101	<.001	<.001	3	7
PDAC	SERPINE2 →	+0.929	+0.073	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048711 vs ITIH1 — PDAC

Explore this scatter interactively →