Positive regulation of astrocyte differentiation

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of astrocyte differentiation pathway differs between tumor and matched normal tissue in 14 of the 18 cancer types tested.

The strongest signal is observed in colon adenocarcinoma (COAD), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as BLCA and KICH, show the opposite pattern, with lower activity in tumor tissue.

COAD, BLCA, and KICH show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
COAD	All	IV	+0.090	<.001	11	view →
BLCA	All	All	−0.135	<.001	10	view →
KICH	All	II,III,IV	−0.108	<.001	8	view →
LUAD	Female	II,III,IV	+0.066	<.001	8	view →
BRCA	All	III,IV	−0.106	<.001	6	view →
KIRC	Male	All	+0.054	<.001	5	view →
HNSC	All	All	+0.047	.003	5	view →
CHOL	All	All	+0.107	<.001	3	view →
LIHC	Male	III,IV	+0.049	<.001	3	view →
THCA	Male	All	+0.059	.012	2	view →
UCEC	All	II,III,IV	−0.049	.042	2	view →
READ	All	All	+0.056	.031	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 14 lineages.

GO:0048711–COAD

Open the COAD breakdown →