Embryonic skeletal system development

Across TCGA cell cohorts, RNA activity of the Embryonic skeletal system development pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAMM41, ETS1, and NUP210, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TAMM41 grouped by Embryonic skeletal system development-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TAMM41 →	+0.439	+0.147	.001	.002	3	4
URINARY_TRACT	ETS1 →	-2.207	-0.298	<.001	.006	3	4
LARGE_INTESTINE	NUP210 →	+1.694	+0.129	.007	.005	2	4
LARGE_INTESTINE	ADD3 →	+1.262	+0.144	.004	.008	3	3
LIVER	BTBD11 →	-1.799	-0.362	.002	.005	3	3
LARGE_INTESTINE	CPT2 →	+0.604	+0.139	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TAMM41 by Embryonic skeletal system development activity — LARGE_INTESTINE

Explore this box plot interactively →