Skeletal system morphogenesis

Across TCGA patient cohorts, RNA activity of the Skeletal system morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCOLCE, CRY2, and MAP1A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Skeletal system morphogenesis activity versus PCOLCE in BRCA (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PCOLCE →	+1.363	+0.880	.003	.001	3	4
COAD	CRY2 →	+0.400	+0.736	<.001	<.001	3	4
COAD	MAP1A →	+0.879	+0.851	<.001	<.001	3	4
COAD	FILIP1L →	+0.809	+0.907	<.001	<.001	3	4
COAD	HIC1 →	+0.688	+0.837	<.001	<.001	3	4
BRCA	ADAMTSL1 →	+0.559	+0.655	.003	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048705 vs PCOLCE — BRCA

Explore this scatter interactively →