Embryonic skeletal system morphogenesis

Across TCGA cell cohorts, RNA activity of the Embryonic skeletal system morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FDXACB1, EAF2, and HSPA1A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic skeletal system morphogenesis activity versus FDXACB1 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	FDXACB1 →	+0.465	+0.167	.006	.002	3	4
OESOPHAGUS	EAF2 →	-0.980	-0.337	.005	<.001	3	4
LARGE_INTESTINE	HSPA1A →	-2.622	-0.234	.001	<.001	3	4
LUNG_NSCLC_LUAD	EXTL2 →	-1.057	-0.233	.001	.001	3	4
STOMACH	ARFGEF3 →	+1.575	+0.224	.003	.004	3	4
CNS	MIA →	+3.306	+0.281	.009	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048704 vs FDXACB1 — UPPER_AERODIGESTIVE_TRACT

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