Embryonic viscerocranium morphogenesis

Across TCGA patient cohorts, RNA activity of the Embryonic viscerocranium morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM161B, ANXA2, and RNU6-834P, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic viscerocranium morphogenesis activity versus TMEM161B in COAD (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TMEM161B →	+0.393	+0.653	.001	.006	3	3
COAD	ANXA2 →	-0.501	-0.541	.004	.008	3	3
COAD	RNU6-834P →	+0.577	+0.559	.004	.003	3	3
LUAD	FBXO16 →	+0.493	+0.367	<.001	<.001	3	3
PDAC	SSC5D →	-0.384	-0.646	.009	.002	3	3
PDAC	LINC01123 →	+0.245	+0.547	.009	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048703 vs TMEM161B — COAD

Explore this scatter interactively →