Embryonic viscerocranium morphogenesis

Across TCGA cell cohorts, RNA activity of the Embryonic viscerocranium morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANKRD1, SPART, and CD63, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ANKRD1 grouped by Embryonic viscerocranium morphogenesis-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ANKRD1 →	-4.202	-1.325	.006	.009	2	5
SOFT_TISSUE	SPART →	-2.827	-0.458	.006	.001	3	3
SOFT_TISSUE	CD63 →	-0.908	-0.385	.007	.006	2	4
LIVER	CCDC88C →	+1.589	+1.475	.004	.009	2	4
LIVER	PRIMPOL →	-1.143	-1.436	.003	.003	3	3
LIVER	CAMK1D →	-2.391	-1.314	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ANKRD1 by Embryonic viscerocranium morphogenesis activity — LIVER

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