Embryonic viscerocranium morphogenesis

Across TCGA cell cohorts, RNA activity of the Embryonic viscerocranium morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTRF1L, YIF1A, and GALNT3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic viscerocranium morphogenesis activity versus MTRF1L in SKIN (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MTRF1L →	+0.544	+0.238	.006	.005	3	6
STOMACH	YIF1A →	-0.754	-0.246	.003	.005	2	7
URINARY_TRACT	GALNT3 →	-3.388	-0.313	.005	.004	3	5
LARGE_INTESTINE	NOC3L →	+0.886	+0.231	<.001	<.001	3	5
LARGE_INTESTINE	TRIM37 →	+1.048	+0.276	<.001	.002	3	5
LARGE_INTESTINE	USP45 →	+1.114	+0.272	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048703 vs MTRF1L — SKIN

Explore this scatter interactively →