Embryonic neurocranium morphogenesis

Across TCGA patient cohorts, RNA activity of the Embryonic neurocranium morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AEBP1, SERPINF1, and FERMT2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic neurocranium morphogenesis activity versus AEBP1 in CCRCC (Pearson r = -0.04).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	AEBP1 →	+0.578	+0.075	.005	<.001	3	8
BRCA	SERPINF1 →	+0.834	+0.063	<.001	<.001	3	8
BRCA	FERMT2 →	+0.432	+0.041	<.001	<.001	3	8
CCRCC	PCOLCE →	+0.588	+0.051	.003	.003	3	8
CCRCC	CNN2 →	+0.373	+0.064	.004	<.001	3	8
BRCA	TIMP2 →	+0.567	+0.050	.002	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048702 vs AEBP1 — CCRCC

Explore this scatter interactively →