Embryonic neurocranium morphogenesis

Across TCGA patient cohorts, RNA activity of the Embryonic neurocranium morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LMBR1L, LAMB1, and XKR8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic neurocranium morphogenesis activity versus LMBR1L in LSCC (Pearson r = -0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LMBR1L →	+0.372	+0.316	<.001	.002	3	4
LSCC	LAMB1 →	+0.612	+0.343	<.001	<.001	3	4
OV	XKR8 →	+0.323	+0.526	.001	<.001	3	3
OV	BCL6B →	+0.450	+0.419	.006	.009	3	3
OV	BNC2 →	+0.870	+0.754	.001	<.001	3	3
OV	DDX47 →	+0.399	+0.569	.001	.003	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048702 vs LMBR1L — LSCC

Explore this scatter interactively →