Embryonic cranial skeleton morphogenesis

Across TCGA cell cohorts, RNA activity of the Embryonic cranial skeleton morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CORO1A, ADAMTSL5, and ZNF341, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CORO1A grouped by Embryonic cranial skeleton morphogenesis-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CORO1A →	-1.656	-0.232	.007	.002	3	4
SOFT_TISSUE	ADAMTSL5 →	+1.551	+0.339	<.001	.001	3	4
CNS	ZNF341 →	+0.301	+0.202	.002	<.001	3	4
BLOOD_Myeloma	ZSCAN21 →	-1.130	-0.304	.005	.002	3	4
BLOOD_Leukemia	EI24 →	+0.867	+0.245	<.001	.002	3	4
BONE	FDXACB1 →	+0.940	+0.252	.003	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CORO1A by Embryonic cranial skeleton morphogenesis activity — BREAST

Explore this box plot interactively →