Embryonic cranial skeleton morphogenesis

Across TCGA cell cohorts, RNA activity of the Embryonic cranial skeleton morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LIMCH1, TOB1, and ABHD14A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic cranial skeleton morphogenesis activity versus LIMCH1 in PANCREAS (Pearson r = -0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	LIMCH1 →	-2.411	-0.251	<.001	<.001	3	5
LUNG_NSCLC_LUAD	TOB1 →	-0.900	-0.155	.006	.004	3	5
OVARY	ABHD14A →	+0.704	+0.197	.007	.001	3	5
PANCREAS	TRABD2A →	+1.963	+0.327	.001	.002	3	4
LIVER	NUDT4 →	+1.048	+0.234	.004	.008	3	4
LARGE_INTESTINE	ATP6AP1 →	-0.910	-0.197	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048701 vs LIMCH1 — PANCREAS

Explore this scatter interactively →