Negative regulation of smooth muscle cell proliferation

Across TCGA cell cohorts, RNA activity of the Negative regulation of smooth muscle cell proliferation pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBM10, KCNIP1, and LHX6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RBM10 grouped by Negative regulation of smooth muscle cell proliferation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	RBM10 →	-0.339	-0.496	<.001	.001	3	5
CNS	KCNIP1 →	-0.167	-0.945	.007	.001	3	4
LIVER	LHX6 →	+0.226	+1.185	<.001	.001	3	3
LIVER	BMP2K →	-0.178	-0.861	<.001	.006	3	3
CNS	PPFIBP1 →	-0.332	-1.045	.001	<.001	3	3
CNS	RHOB →	-0.212	-0.958	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RBM10 by Negative regulation of smooth muscle cell proliferation activity — BREAST

Explore this box plot interactively →