Negative regulation of smooth muscle cell proliferation

Across TCGA cell cohorts, RNA activity of the Negative regulation of smooth muscle cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM39B, VIRMA, and RILPL2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMEM39B grouped by Negative regulation of smooth muscle cell proliferation-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TMEM39B →	+0.783	+0.913	.004	.002	3	6
STOMACH	VIRMA →	+0.693	+1.078	<.001	.002	3	5
SOFT_TISSUE	RILPL2 →	-0.921	-1.361	.001	<.001	3	4
BLOOD_Lymphoma	KCNQ5 →	+0.667	+1.669	.001	<.001	3	4
LARGE_INTESTINE	CGRRF1 →	+0.521	+0.620	.005	.002	3	4
LARGE_INTESTINE	EFCAB12 →	+0.406	+0.890	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMEM39B by Negative regulation of smooth muscle cell proliferation activity — OESOPHAGUS

Explore this box plot interactively →