Animal organ formation

Across TCGA cell cohorts, RNA activity of the Animal organ formation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDAP1, MFSD10, and TMEM109, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Animal organ formation activity versus PDAP1 in OVARY (Pearson r = -0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PDAP1 →	-0.751	-0.320	.001	<.001	3	1
OVARY	MFSD10 →	+1.477	+0.468	<.001	.001	3	1
OVARY	TMEM109 →	-0.753	-0.275	.001	.004	3	1
OVARY	SCNN1A →	+3.065	+0.387	.007	.002	3	1
OVARY	KCTD20 →	-0.919	-0.276	.001	.004	3	1
OVARY	MCM3 →	-1.616	-0.391	.005	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048645 vs PDAP1 — OVARY

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