Regulation of skeletal muscle tissue development

Across TCGA cell cohorts, RNA activity of the Regulation of skeletal muscle tissue development pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANKEF1, BCKDHB, and MYO5A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of skeletal muscle tissue development activity versus ANKEF1 in LARGE_INTESTINE (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ANKEF1 →	+1.012	+0.252	.003	.004	3	4
LARGE_INTESTINE	BCKDHB →	+1.141	+0.302	.001	.002	3	4
BONE	MYO5A →	+1.522	+0.185	.001	.004	3	4
LUNG_NSCLC_LUSC	MRFAP1 →	+0.687	+0.441	.004	.001	3	4
STOMACH	LRIG3 →	+1.677	+0.410	.008	.001	3	4
KIDNEY	CHST7 →	+1.555	+0.363	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048641 vs ANKEF1 — LARGE_INTESTINE

Explore this scatter interactively →