Regulation of skeletal muscle tissue development

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of skeletal muscle tissue development pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 26 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher Regulation of skeletal muscle tissue development pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRC and ACC, show the opposite pattern, with higher activity associated with better survival.

KIRC, ACC, and UCS are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.919	0.836	<.001	108	view →
ACC	DFS	Tertile	All	0.679	0.274	<.001	68	view →
UCS	OS	Quartile	III,IV	0.728	0.250	.002	56	view →
LGG	OS	Median	All	0.324	0.530	<.001	52	view →
LIHC	OS	Quartile	All	0.771	0.392	<.001	23	view →
SARC	DFS	Tertile	All	0.706	0.508	.002	14	view →
LUAD	OS	Median	II,III,IV	0.347	0.173	.013	13	view →
HNSC	DFS	Quartile	III,IV	0.450	0.274	.018	7	view →
DLBC	DFS	Median	III,IV	1.000	0.146	.017	6	view →
COAD	DFS	Tertile	IV	0.306	0.527	.017	6	view →
PAAD	DFS	Quartile	All	0.209	0.429	.041	6	view →
LUSC	DFS	Quartile	III,IV	0.393	0.879	.046	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0048641–KIRC (OS)

Open the KIRC breakdown →