Negative regulation of muscle organ development

Across TCGA patient cohorts, RNA activity of the Negative regulation of muscle organ development pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TLN2, CRTAP, and GSN, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of muscle organ development activity versus TLN2 in BRCA (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TLN2 →	+0.446	+0.067	<.001	<.001	3	7
BRCA	CRTAP →	+0.707	+0.085	<.001	<.001	3	7
PDAC	GSN →	+0.704	+0.100	<.001	<.001	3	7
BRCA	ITGB5 →	+0.676	+0.095	<.001	<.001	3	7
OV	LRP1 →	+0.655	+0.119	<.001	<.001	3	7
LSCC	APBB2 →	+0.373	+0.092	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048635 vs TLN2 — BRCA

Explore this scatter interactively →