Camera-type eye morphogenesis

Across TCGA patient cohorts, RNA activity of the Camera-type eye morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PARVA, VCAN, and LTBP3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Camera-type eye morphogenesis activity versus PARVA in BRCA (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PARVA →	+0.473	+0.029	<.001	<.001	3	9
OV	VCAN →	+0.995	+0.037	.001	<.001	3	8
OV	LTBP3 →	+0.739	+0.039	<.001	<.001	3	8
BRCA	FERMT2 →	+0.607	+0.031	<.001	<.001	3	8
OV	RAI14 →	+0.408	+0.038	.001	.001	3	8
OV	SEPTIN11 →	+0.405	+0.039	.002	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048593 vs PARVA — BRCA

Explore this scatter interactively →