Camera-type eye morphogenesis

Across TCGA pan-cancer cohorts, RNA activity of the Camera-type eye morphogenesis pathway differs between tumor and matched normal tissue in 9 of the 18 cancer types tested.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as BRCA and KICH, show the opposite pattern, with lower activity in tumor tissue.

LIHC, BRCA, and KICH show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
LIHC	Female	II,III,IV	+0.025	<.001	7	view →
BRCA	Female	II,III,IV	−0.030	<.001	6	view →
KICH	All	All	−0.024	<.001	6	view →
HNSC	All	II,III,IV	+0.015	.004	6	view →
STAD	All	II,III,IV	+0.029	.006	4	view →
CHOL	All	All	+0.027	<.001	2	view →
UCEC	All	All	−0.022	.011	2	view →
THCA	All	All	−0.010	.013	2	view →
KIRC	Male	III,IV	−0.011	.004	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 9 strongest of 9 lineages.

GO:0048593–LIHC

Open the LIHC breakdown →