Camera-type eye morphogenesis

Across TCGA pan-cancer cohorts, RNA activity of the Camera-type eye morphogenesis pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 133 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher Camera-type eye morphogenesis pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and PRAD, show the opposite pattern, with higher activity associated with better survival.

HNSC, LGG, and MESO are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.719	0.522	<.001	133	view →
LGG	DFS	Tertile	All	0.632	0.797	<.001	44	view →
MESO	DFS	Tertile	II,III,IV	0.268	0.500	.010	39	view →
CESC	OS	Tertile	III,IV	0.473	0.745	.014	26	view →
THCA	OS	Tertile	All	0.958	1.000	.002	26	view →
KICH	OS	Quartile	All	0.625	1.000	.044	9	view →
OV	DFS	Quartile	IV	0.329	0.512	.045	6	view →
READ	DFS	Tertile	IV	0.233	0.662	.030	6	view →
ESCA	DFS	Median	IV	0.221	0.539	.046	6	view →
PRAD	OS	Quartile	All	1.000	0.785	.025	4	view →
ACC	DFS	Quartile	II,III,IV	0.185	0.646	.021	4	view →
KIRP	OS	Median	IV	0.044	0.522	.044	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0048593–HNSC (DFS)

Open the HNSC breakdown →