Camera-type eye morphogenesis

Across TCGA patient cohorts, RNA activity of the Camera-type eye morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KYNU, PPP2R1A, and PLXNC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Camera-type eye morphogenesis activity versus KYNU in GBM (Pearson r = -0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	KYNU →	-0.768	-1.158	<.001	<.001	3	5
OV	PPP2R1A →	+0.558	+0.786	.002	.003	3	5
GBM	PLXNC1 →	-0.612	-0.870	.005	.005	3	4
GBM	ADCY7 →	-0.728	-0.918	<.001	<.001	3	4
GBM	SECTM1 →	-0.905	-1.015	<.001	<.001	3	4
LUAD	CRYBA1 →	+0.414	+0.809	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048593 vs KYNU — GBM

Explore this scatter interactively →