Anatomical structure arrangement

Across TCGA patient cohorts, RNA activity of the Anatomical structure arrangement pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LAMB1, SPON2, and TECR, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Anatomical structure arrangement activity versus LAMB1 in LUAD (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	LAMB1 →	+0.319	+0.049	<.001	<.001	3	7
OV	SPON2 →	+0.861	+0.062	.008	.002	3	6
LUAD	TECR →	-0.324	-0.068	<.001	<.001	3	6
LSCC	C6 →	+0.553	+0.061	<.001	.001	3	6
COAD	AEBP1 →	+0.476	+0.035	.006	.003	3	6
LSCC	CPB2 →	+0.631	+0.081	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048532 vs LAMB1 — LUAD

Explore this scatter interactively →