Anatomical structure arrangement

Across TCGA patient cohorts, RNA activity of the Anatomical structure arrangement pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HTR2A, ARRB1, and SLC48A1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Anatomical structure arrangement activity versus HTR2A in GBM (Pearson r = -0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HTR2A →	+0.791	+0.686	<.001	<.001	3	3
GBM	ARRB1 →	+0.519	+0.562	<.001	.001	3	3
UCEC	SLC48A1 →	+0.521	+0.657	.004	.001	3	3
LUAD	ITGB2-AS1 →	+0.828	+0.549	.001	.004	3	3
UCEC	PECAM1 →	+0.536	+0.567	<.001	.004	3	3
UCEC	FSBP →	-0.507	-0.652	.006	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048532 vs HTR2A — GBM

Explore this scatter interactively →