Anatomical structure arrangement

Across TCGA cell cohorts, RNA activity of the Anatomical structure arrangement pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACVR1B, DAB1, and NRP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ACVR1B grouped by Anatomical structure arrangement-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ACVR1B →	-0.134	-0.770	.002	.001	3	5
BREAST	DAB1 →	-0.239	-0.830	<.001	.001	3	5
UPPER_AERODIGESTIVE_TRACT	NRP1 →	-0.286	-1.302	.003	.005	2	6
KIDNEY	HSPA5 →	-0.320	-1.469	.006	.001	2	6
SOFT_TISSUE	OR51B6 →	-0.548	-1.806	<.001	.003	3	4
BLOOD_Myeloma	FEN1 →	-0.615	-2.080	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ACVR1B by Anatomical structure arrangement activity — BREAST

Explore this box plot interactively →