Anatomical structure arrangement

Across TCGA cell cohorts, RNA activity of the Anatomical structure arrangement pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STAG3L5P-PVRIG2P-PILRB, VSTM2A, and HOMER2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, STAG3L5P-PVRIG2P-PILRB grouped by Anatomical structure arrangement-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	STAG3L5P-PVRIG2P-PILRB →	+0.215	+0.138	.001	.001	3	3
SKIN	VSTM2A →	+0.177	+0.102	<.001	.001	3	3
OESOPHAGUS	HOMER2 →	+0.187	+0.139	<.001	<.001	3	3
LARGE_INTESTINE	PTENP1 →	+0.261	+0.135	.002	.005	3	3
LUNG_SCLC	KLHL29 →	+0.395	+0.215	.004	.008	3	2
LUNG_SCLC	CPM →	+0.290	+0.157	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

STAG3L5P-PVRIG2P-PILRB by Anatomical structure arrangement activity — PANCREAS

Explore this box plot interactively →