Anatomical structure arrangement

Across TCGA cell cohorts, RNA activity of the Anatomical structure arrangement pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GOLGA6L10, PPIP5K1, and SLC30A4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Anatomical structure arrangement activity versus GOLGA6L10 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	GOLGA6L10 →	+1.039	+0.157	.001	.009	3	5
SKIN	PPIP5K1 →	+0.696	+0.145	<.001	.006	3	4
BREAST	SLC30A4 →	+0.807	+0.133	<.001	.002	3	4
BREAST	PCNX3 →	+0.438	+0.141	.008	.006	3	4
LUNG_SCLC	CASKIN1 →	+1.411	+0.156	.005	.001	3	4
LUNG_SCLC	CROCC →	+2.238	+0.123	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048532 vs GOLGA6L10 — UPPER_AERODIGESTIVE_TRACT

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