Across TCGA patient cohorts, RNA activity of the Axial mesoderm development pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.
The most reproducible pathway-associated proteins across cancer lineages are ALDH1A1_S413, ANK2_S3765, and STK4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.
Each partner is linked to its corresponding Q-omics profile.